According to the latest study published in "The Lancet Gastroenterology and Hepatology" journal,
more than 300 cases of acute hepatitis in children of unknown cause in more than 20 countries and regions around the world may be associated with the super antigen of the Coronavirus.
Researchers suggest that the recent cases of acute hepatitis in children were probably the result of a coronavirus infection,
followed by an adenovirus infection after the emergence of a viral reservoir in the intestinal tract.
The persistence of Coronavirus in the gastrointestinal tract of children results in repeated release of viral proteins in intestinal epithelial cells, leading to immune activation.
If evidence of a Coronavirus superantigen-mediated immune activation is found, immunomodulatory therapy should be considered.
The WHO Regional Office for Europe reported on May 13
that unexplained acute hepatitis cases in children aged 16 and under showed that more than 70% had been infected with the Coronavirus.