What's the problem?
What's troubling/bothering you?
What's on your mind?
What are you so concerned/worried about?
Why the long face?
What's with the long face?
Is everything okay/alright?
It looks like something's bothering/troubling you.
What's going on?/What's up with you?
I'm really concerned/worried about it.
I couldn't sleep a wink.
What could I have done with it?
I've got something that I need to talk to you about.
A: Hello, Mrs summers. This is Mrs Lee. John hasn't come home yet, and I'm getting a little concerned. What time did he leave there?
B: About an hour ago. But I wouldn't worry too much. You know how boys are.
A: Yeah, I know. But it usually only takes him thirty minutes to walk home.
B: Maybe he stopped off at a friend's house.
A: Yeah. Maybe you're right...Oh, wait. I think I hear the door opening now.
1.It takes sb+一段时间+to do
It takes her/him/us/me/you/them two weeks to finish the work.
例句：I'll stop off in Paris for a few days to visit my cousins.