That person is so rude.
How rude can you be?
That really makes me mad/angry/upset.
He drives me crazy when he does that.
She is the most unpleasant woman I've ever met.
I'm mad/angry/upset about what you said.
Because of you, I'm in a bad mood.
That makes me feel bad/unhappy/upset.
Things like that are what really burn me.
Things like that really drive me crazy.
I'm feeling a little bitter about what happened.
I'm not happy about what you did.
Those kinds of situations put me in a bad mood.
A: What's wrong? You don't look too happy.
B: No, I'm not.
A: Why? What happened?
B: I was talking with a customer who came into the office today. He was going to ABC University and he made a remark about DEF University which I went to. That really put me in a bad mood.
A: Try not to let it get to you. Why don't you sit down here? I'll give you a massage.
1.What's wrong?还可以说：What's wrong with you?或What's the matter(with you)?
2.You don't look too happy.还可以说：You look unhappy/upset.
3.get to sb表示“影响到某人”