What's wrong with you?/What's the problem?/What's troubling you?

有什么问题吗？/什么事让你困扰？

What's on your mind?

你在想什么？

What are you concerned about?

你在担心什么？

Why the long face?

为什么板着一张脸？

Is everything oK?

一切都还好吗？

What's going on?/What's up with you?

发生了什么？

Dialogue1

A: What's wrong with you?

你怎么了？

B: I just lost my job and now I don't know how I'm going to pay my bills.

我刚刚丢了工作，现在不知道该怎么支付我的那些账单。

Dialogue2

A: You don't look too happy. What's up with you?

你看起来不太开心，你怎么了？

B: I just took my midterm exam and I think I bombed it.

我刚刚参加了期中考试，我觉得我考砸了。

bomb在这里指“不成功”，“失败”。

A: Hello, Mrs Summers. This is Mrs Li. Mike hasn't come home yet, and I'm getting a little concerned. What time did he leave school?

萨默斯夫人，您好，我是李太太。迈克现在还没有到家，我有点担心，请问他是什么时候离开学校的？

B: About an hour ago. But I wouldn't worry too much, you know how boys are.

大约一个小时以前，不过我觉得不用太担心，你知道男孩子嘛。

A: Yeah, I know. But it usually only takes him thirty minutes to walk home.

是的，我明白，但是他通常只要步行30分钟就能到家了。

B: Maybe he stopped off at a friend's house.

他可能中途去朋友家了。

A: Yeah. Maybe you're right. Oh, wait, I think I hear the door opening now.

可能是这样。哦，等一下，我好像听到开门了。