I'm really angry with him!
be angry with sb
Are you angry with me for some reason?
be angry about sth
I was very angry about the rumours.
A:Why are you so depressed,Tommy?
B:Nothing.I'm just tired.
A:Come on,Tommy.You can tell me!
B:The boss gave me such a lot of work to do!I was working until 10 o'clock yesterday.And it has not been finished!
A:Why don't you talk to your boss?
B:I have talked to him.But he just said he couldn't find another person to help me.I'm really angry with him.
A:Tommy,just relax.I think your boss understands how hard you are working.
B:I hope so.