A: Will you please go and see him?
B: What is wrong with him?
A: He is always running himself through the mill for his failure.
B: I would talk to him.
run sb. through the mill：折磨某人（尤为指精神上的折磨）
e.g. It runs himself through the mill for the fear that he was not receiving adequate credit.
e.g. Juliet ran herself through the mill for she had the desire to keep Romeo near her but she also had the fear for his life: should his presence be detected.
Will you please……请你……好吗？
e.g. Will you please send these dirty clothes to the laundry?
e.g. Will you please sum up the main ideas of this article?
What is wrong with… ……怎么啦？
e.g. What is wrong with old age if the guy is healthy?
e.g. Does she know what is wrong with it?