原文视听

It had already been established that like mice,
这种联系已经开始在老鼠身上建立了
normal yeast lives longer on a calorie restricted diet.
正常酵母在控制卡路里后活得更长了
So with this in mind,
所以以此为基础
David removed the gene that triggered longevity
大卫去掉了长寿基因
and put this genetically modified yeast
再对此转基因酵母
on a calorie restricted diet to see if it still worked.
进行卡路里摄入限制 看这是否还有效
What the team discovered was that when this gene wasn't there
研究组发现当这个基因不再
any more in the yeast cells,
出现在酵母细胞内时
they didn't respond to the diet calorie restriction.
它们便对卡路里摄入限制没反应了
They didn't live longer so we knew that this gene,
细胞很快死去 因此我们得知这个基因
maybe others, were really important for this diet to work.
或者其他基因 对这种节食真的很重要
What was a really amazing discovery
有个惊人的发现
was to realise that this diet and these genes were part
就是这种节食和这些基因是同一系统的
of the same system, and that was a real breakthrough.
那才是真正的内幕
David felt he'd cracked it.
大卫觉得他有了突破
He'd shown that without the particular gene he'd identified,
他已证实没有他发现的那个特殊基因
calorie restriction would never work,
不管你吃得有多么的少
no matter how little you ate.
卡路里摄入限制就不再会有效
But what if he could find a
但他若能找到一种
drug that would activate this longevity gene
激活这个长寿基因的药
and mimic the effect of the diet.
那就会有这种节食的效果了

重点解释

they didn't respond to the diet calorie restriction.它们便对卡路里摄入限制没反应了

respond to:响应； 对 ... 起反应

The patient did not respond to treatment.

病人经治疗後未见起色。

They were prompt to respond to our call for help.

他们对我们的求助迅即回应。

calorie restriction would never work,no matter how little you ate.不管你吃得有多么的少卡路里摄入限制就不再会有效

no matter:无论； 不管

Recently, I feel tired no matter what I do.

最近我无论做什么都会疲劳。

Don't open the door, no matter who calls!

无论谁来，都不要开门！

词汇搭配:

no matter what无论什么

no matter who无论谁

no matter when无论何时

no matter where无论何处

no matter how无论如何

It is no matter.没关系,无关紧要...

It makes no matter.没关系,无关紧要...

no laughing matter不是闹着玩的事...