Hold that thought. Leonard, a moment.
暂停！莱纳德，过来一下。
Let me guess. You have a problem with this.
我猜，你有点意见。
Where do I begin?
我该从哪里说起呢？
It's up to you. Crazy person's choice.
随你便，疯子的选择。
——《生活大爆炸》

be up to sb. 由 ... 决定

I leave it up to you.
我让你自己决定。
It's up to him to do it.
这事该由他做。
It's up to you to decide whether to go or to stay.
是去是留该由你决定。
It's up to you to decide.
这主要取决于你。
.I'd give you my advice; whether or not you act on it is up to you.
办法我已经告诉你了；是否照办是你的事。