解释：

1，弄糟，弄乱，搞砸(to mess up )

例句：

I hope I don't screw up this time.
我希望这次不会搞砸了。

Try again and don't screw it up this time.
再试一次，这次别搞砸了。

2，如果是screw up somebody 或者screw somebody up的结构，意思是“伤害到某人(to confuse or hurt someone)"，

例句：

Their parents' divorce really screwed up the kids.
父母的离婚伤害了孩子。