1. We should make every effort to...
我们应该竭尽全力…….

We should make every effort to protect our valuable drinking water.
我们应该竭尽全力保护我们宝贵的淡水.

2. What do you find the hardest in...
你觉得……最大的困难是什么

What do you find the hardest in learning English 你觉得学英语最大的困难是什么

3. What do you mean by...
你……是什么意思

What do you mean by telling me a lie 你跟我撒谎是什么意思

4. What do you say...
你认为……怎么样

What do you say we go for a drive one of these days when it clears up？
找一天天晴的时候我们开车出去兜兜风,你认为怎么样

5. What do you think of...
你认为……怎么样

What do you think of the relationship between China and America？
你认为中美关系如何？

6. What I'm getting at is...
我的意思是…….

What I'm getting at is that he deserves this promotion.
我的意思是他被提升是理所应当的.

7. What is more serious is that...
更严重的是…….

What is more serious is that you didn't realize your mistake.
更严重的是你没有意识到自己的错误.

8. What's the point of...
……意义何在 为什么要……

What's the point of arguing about it
争论这件事意义何在

9. What makes you think...
是什么让你认为……/ 你为什么认为……

What makes you think he will show up？
是什么让你认为他会来？

10. What seems to be the problem with...
……大概是什么问题

What seems to be the problem with the computer? It doesn't work smoothly.
这电脑大概出了什么问题?运行得很不顺.