科学美国人60秒:吸入核糖核酸可能有助于治疗囊性纤维病
日期:2019-09-04 11:46

(单词翻译:单击)

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听力文本

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This is Scientific American — 60-Second Science. I'm Christopher Intagliata.
Your genome is sort of like a library — with each gene an instruction manual for making proteins. Bad news is, you can't return a book and take out a new edition. But the technique of gene therapy allows you to revise your copy of the book, so to speak...giving you the ability, potentially, to make new and different proteins.
Now scientists have experimented with a new way to make text revisions — by inhaling the changes. They tested the concept by having mice breathe in genetic material called messenger RNA, or mRNA. For the test, the mRNA included instructions to manufacture luciferase — the stuff that lights up in fireflies.
The researchers packaged the mRNA with a degradable polymer, to trick the mice's lung cells into accepting the package. And once the cells gobbled it up, they began to glow — proving that inhaling mRNA is an effective way to kick-start the production of new and novel proteins, like the firefly enzyme.

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The scientists also repeated the experiment in mice whose cells had been genetically engineered to turn permanently red if they received a copy of mRNA — making it possible to count the proportion of cells affected by a dose. The proof of concept is in the journal Advanced Materials.
Of course, the point isn't to make mice glow. Instead, one idea is to use this technique to help cystic fibrosis patients. Because people with CF have a genetic mutation that causes a buildup of sticky mucus in their lungs. Several of the study authors work with a publicly traded biotech company called Translate Bio, which is conducting phase 1 and 2 trials to determine if inhaling messenger RNA could provide a genetic fix for cystic fibrosis. Regardless of the particular case of CF, the luciferase example shows that inhalation genetic therapy could be an inspiration.
Thanks for listening for Scientific American — 60-Second Science. I'm Christopher Intagliata.

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参考译文

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这里是科学美国人——60秒科学DKtb;Ap#VCP。我是克里斯托弗·因塔利亚塔73TW[zu1D9a)woq,xU
你的基因组有点像图书馆——每个基因都是制造蛋白质的操作手册SKOo3uP+Uj4~d;。坏消息是,你不能还回一本书之后再借出新版本AV*41Nt6XX。不过,基因治疗技术允许你修订你的书,也就是说,赋予你潜在的能力去制造全新且不同的蛋白质M_wpSmj).si)
现在,科学家已经尝试了一种文本修订的新方法,即吸入这些变化IEe,liX;@2^Vl09。他们让老鼠吸入被称为信使核糖核酸(mRNA)的遗传物质,以此来测试这一概念Fac5;ju%MX31[]f。为了进行测试,信使核糖核酸中包含了制造荧光素酶的指令,荧光素酶是能令萤火虫发光的物质.4q6|Ut89R5
研究人员用可降解聚合物包裹信使核糖核酸,诱使老鼠的肺细胞接受V0laYHdo4c+zTm(CS1S#。一旦肺细胞将其吞噬,肺细胞就会开始发光,这证明吸入信使核糖核酸是启动制造全新蛋白质(如荧光素酶)的有效方法xQS78FYX]__o;1LKRlw6
科学家还在细胞经过基因改造的老鼠身上重复了这项实验,这些老鼠接受信使核糖核酸后,它们的细胞就会永久变红,这使研究人员得以计算受信使核糖核酸剂量影响的细胞比例+(%opZ*pqSa,kOmY。这一概念的验证结果发表在《先进材料》期刊上i(q-fw#fN9HS.wR
当然,关键不是让老鼠发光AfHHZ1r&|;。相反,其中一种想法是,利用这项技术帮助囊性纤维病患者BrNXh=S#&=%Hp=。因为囊性纤维病患者有一种基因突变,会导致其肺部堆积粘液zXl!zEL(|~)bv。这项研究的多名作者与上市生物科技公司Translate Bio合作,该公司正在进行第一阶段和第二阶段的实验,以确定吸入信使核糖核酸能否提供囊肿性纤维病的基因修复方法;=QUZG-sndyB(V(。无论囊肿性纤维病的具体案例情况如何,荧光素酶的例子表明吸入基因治疗可能是条妙计v7;|[uToT(&B7OI
谢谢大家收听科学美国人——60秒科学.x)Jr[3bUoQ%eR。我是克里斯托弗·因塔利亚塔N~i;58Z-2f5Y

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译文为可可英语翻译,未经授权请勿转载!

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重点讲解

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重点讲解:
1. so to speak 可以说;可谓;
I ought not to tell you but I will, since you're in the family, so to speak.
我本来不该告诉你的,但我还是要这么做,因为好歹你是家里的一员)kU3uMO!5;BH
2. breathe in 吸入;吸气;
Place your hands on the small of your back and breathe in.
双手置于腰部,吸气=06PT.6_zM&R]G+N
3. trick sb. into sth./doing sth. 诱使某人做某事;
He tricked me into lending him 100 pounds.
他骗我借给了他100英镑DYjhC!ASSnCz
4. regardless of 不顾;不管;不论;
The fields give high and stable yields regardless of climatic circumstances.
不管天气条件如何,这块地总是保持稳产高产9L&*IEe02Wqkn(

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重点单词
  • messengern. 报信者,先驱
  • enzymen. 酶
  • advancedadj. 高级的,先进的
  • genomen. [生]基因组;[生]染色体组
  • particularadj. 特殊的,特别的,特定的,挑剔的 n. 个别项目
  • permanentlyadv. 永久地
  • conceptn. 概念,观念
  • genen. 基因
  • revisen. 校订,修正,再校稿 v. 校订,修正,校正
  • potentiallyadv. 潜在地