科学美国人60秒:“基因电路”为细胞计算机铺平道路
日期:2016-04-06 14:48

(单词翻译:单击)

听力文本

Our smartphones, tablets, laptops—they all compute things electronically. But, think outside that silicon box for a second: "There's nothing special about electrons and using silicon as part of computing." Chris Voigt, a bioengineer at M.I.T.. "You can do computing with any number of things." Including, he says, DNA.
"Cells do computing all the time. So they're constantly trying to interpret their environment and be able to turn on different genes and respond to it." And those genes in a cellular circuit are like the logic gates, the memory, and other systems found in conventional computers.
So Voigt and his colleagues created what he calls the first human-made "programming language" for living cells. It’s an open-source design environment called "Cello." Just write what you want the cell to do, and Cello spits out the DNA sequence—as if you were compiling code. The researchers used the platform to design 60 genetic circuits, which they then ran inside E. coli bacteria. Many of these DNA-based circuits allow bacteria to sense environmental data - like levels of oxygen or glucose in the gut - and respond in various ways. They detail the findings in the journal Science.
Not all the circuits worked as intended. A quarter of them failed, and some were toxic to the cells. But the idea is to make cellular circuit design easier—and more approachable—to creative people. "When I was a graduate student I had a computer file for Microsoft Word that had all my favorite pieces of DNA. And I would have to sit there and stitch it together and try to remember how each one worked, and constantly run programs to try to look for mistakes."
Cello takes care of all that. And now, Voigt says, biology is right about where electrical engineering was in the early 80s: ready for a computing revolution.

参考译文

我们的智能手机、平板电脑、笔记本——它们都是以电子方式进行计算。但是,考虑一下硅制盒子之外的事物:“利用电子和硅进行计算并无特殊之处。” 克里斯•沃伊特是麻省理工学院的生物工程师。“你可以利用计算机计算任何事物的数量。” DNA也包括在内。
“细胞一直都在进行计算。所以,它们一直在试图了解周围的环境,并控制DNA,并对其作出反应。”这些在细胞电路中的基因就像传统电脑中的逻辑门、内存和其他的系统。
所以,沃伊特和同事们创造了人类首例的活细胞“编程语言”。这种开放源码的设计环境称为“Cello”。你只需写下需要细胞做些什么,这时候 Cello翻译DNA序列——就好像你在进行编码。研究人员利用这一平台设计了60个遗传电路,他们可以利用这些遗传电路应用于大肠杆菌内部。许多基于 DNA的电路都允许细菌感觉环境数据——例如大肠中的氧气以及葡萄糖的含量——并通过不同的方式作出反应。该研究结果发表在《科学》杂志上。

基因电路”.jpg


但是并不是所有的电路都会按照预期的方式运行。有1/4的电路失败了,而有的电路则会毒害细胞。但是,这种创作想法会使有创新精神的人将细胞电路设 计更加简单——更易成功。“当我还在读研究生的时候,我有一个电脑文件里面包含了我最爱的DNA片段。我会坐在那里,将这些片断拼接到一起,并试图记住这 些片断是如何运作的,我还经常运行程序试图找到其中的错误。”
Cello会处理以上所有的问题。现在,沃伊特称生物学就像80年代早期的电器工程:已经为计算机革命做好准备。

重点讲解

1. for a second 一会儿
例句: Tomasz was not aware that he was on air, and whilst the gesture was only shown for a second, it was not acceptable.

托马斯当时并没有注意到正在直播,而这个动作只是瞬间闪现了一下,这是不可接受的。


2. be able to 至少
例句: I'm sure the girl will be able to look out for herself.
我相信女孩会自己照料好自己的。


3. a quarter of 到达
例句: He faces a Democratic opponent who, at 46, is his junior by a quarter of a century.
他面对的民主党对手,年仅46岁,比他足足小了四分之一个世纪。


4. stitch together 凝聚
例句: But they are also forced to stitch together their own code of behavior.
他们也同时被迫将自己的不同标准和行为编织在一起。

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重点单词
  • siliconn. 硅
  • respondv. 回答,答复,反应,反响,响应 n. [建]壁
  • conventionaladj. 传统的,惯例的,常规的
  • intendedadj. 故意的,有意的;打算中的 n. 已订婚者 v.
  • bacterian. (复数)细菌
  • gesturen. 手势,姿态 v. 作手势表达
  • cellon. 大提琴
  • environmentn. 环境,外界
  • celln. 细胞,电池,小组,小房间,单人牢房,(蜂房的)巢室
  • stitchn. 一针,疼痛,碎布条 v. 缝合