This first time, a man named Richard Greville took a group of people to Roanoke Island and then went back to England to get supplies,
which are the things that people need to survive, like food, cloth, and tools.
However, his return to Roanoke Island was delayed (or happened later than the people had expected).
Without these important supplies, the people who lived there decided to leave the island when they had an opportunity and went back to England.
In 1587, another group was left on Roanoke Island and the leader, John White, went back to England for supplies.
But he was not able to come back as quickly as he had planned,
because England was at war with (or fighting with) Spain and wanted to have all the ships for that war.
John wasn't able to go back to Roanoke Island until 1590, three years after he had left.
When he got there, everyone had disappeared, meaning that no one was there.
Nobody knew where they had gone.
Some people think that the colonists might have been killed or kidnapped (or taken away) by Native Americans.
Other people think that they might have died in a storm while trying to go to another island.
We will probably never know the true fate (or what actually happened) of the 117 people on the Lost Colony of Roanoke Island.